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Scheme 1 shows the synthesis of 1,3,4 -thiadiazole-5- ..


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25660-70-2 | 2-Amino-5-thioethyl-1,3,4-thiadiazole - …

46. Chen EY, DeRan MT, Ignatius MS, Grandinetti KB, Clagg R, McCarthy KM. . Glycogen synthase kinase 3 inhibitors induce the canonical WNT/beta-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma. 2014;111:5349-54

Selected Analogs of 5-Imino-1,2,4-Thiadiazoles Acting as GSK-3 inhibitors

146. Hicks JW, Wilson AA, Rubie EA, Woodgett JR, Houle S, Vasdev N. Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [11C-carbonyl] AR-A014418 by [11C]CO2 fixation. 2012;22:2099-101

Synthesis of 1,3,4-oxadiazoles - Organic Chemistry Portal

12. Yucel G, Oro AE. Cell migration: GSK3beta steers the cytoskeleton's tip.  2011;144:319-21

79. Saitoh M, Kunitomo J, Kimura E, Hayase Y, Kobayashi H, Uchiyama N. . Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta. 2009;17:2017-29

78. Yngve U, Soderman P, Svensson M, Rosqvist S, Arvidsson PI. Imidazopyridine-based inhibitors of glycogen synthase kinase 3: synthesis and evaluation of amide isostere replacements of the carboxamide scaffold. 2012;9:2442-52

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18. Cohen P, Goedert M. GSK3 inhibitors: development and therapeutic potential.  2004;3:479-87

44. Denham M, Bye C, Leung J, Conley BJ, Thompson LH, Dottori M. Glycogen synthase kinase 3beta and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage. 2012;30:2400-11

42. Tan M, Ma S, Huang Q, Hu K, Song B, Li M. GSK-3alpha/beta-mediated phosphorylation of CRMP-2 regulates activity-dependent dendritic growth. 2013;125:685-97

24. Hur EM, Zhou FQ. GSK3 signalling in neural development.  2010;11:539-51
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    2013 Oct 21;4(20):5224-5227.

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    28. Eldar-Finkelman H, Martinez A. GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS. 2011;4:32

  • Aerobic Copper-Catalyzed Organic Reactions - …

    30. Llorens-Maritin M, Jurado J, Hernandez F, Avila J. GSK-3beta, a pivotal kinase in Alzheimer disease. 2014;7:46

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Allen was born in 1984 in Kutztown, Pennsylvania

GSK-3, glycogen synthase kinase-3; nM, nanomolar; ATP, adenosine triphosphate; GS, glycogen synthase; PI-3 kinase, phosphatidylinositol-4, 5-bisphosphate 3-kinase; PKB, protein kinase B; BD, bipolar disorder; AD, Alzheimer's disease; Wnt pathway, a pathway that transfers signals from the outside of the cell to the inside of the cell through cell surface receptors; β-catenin, cadherin association protein; KDa, kilodalton; IC50, the half maximal inhibitory concentration; SAR, structure activity relationship; HBD, hydrogen bond donor; HBA, hydrogen bond acceptor; PBMC, peripheral blood mononuclear cells; AIDS, acquired immunodeficiency syndrome; Pgp, P-glycoprotein; PET, positron emission tomography; MDR-MDCK assay, a permeability assay using Madin-Darby canine kidney cells with the gene; CDK1, cyclin-dependent kinase 1; ERK2, extracellular signal-regulated kinase 2, also known as mitogen activated protein kinase; IL-8, interleukin 8; ZDF, Zucker diabetic fatty; PIM1, proto-oncogene serine/threonine-protein kinase; PAK1, serine/threonine-protein kinase 1; DAPK1, death-associated protein kinase 1; MLCK, myosin light-chain kinase; FLT4, fms-related tyrosine kinase 4; CK2, casein kinase-II; CLK1, dual specificity protein kinase; PD, Parkinson's disease; HD, Huntington's disease; CNS, central nervous system; TMED, threshold minimum effective dose; TDZD, Thiadiazolidinones; PKA, protein kinase A; PKC, protein kinase C; PSP, progressive supranuclear palsy; MMSE, mini-mental status examination, cGMP, current Good Manufacturing Practice; and ITDZ, 5-imino-1, 2, 4-thiadiazole.

Materials for OLED and PLED | QCR Solutions Corp

2. Summers SA, Kao AW, Kohn AD, Backus GS, Roth RA, Pessin JE. . The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism. 1999;274:17934-40

Materials for the Creation of OLED and PLED | QCR Solution Corp

3. Lochhead PA, Coghlan M, Rice SQ, Sutherland C. Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression. 2001;50:937-46

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4. Ciaraldi TP, Oh DK, Christiansen L, Nikoulina SE, Kong APS, Baxi S. . Tissue-specific expression and regulation of GSK-3 in human skeletal muscle and adipose tissue. 2006;291:E891-E8

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