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So far, 28 types of collagen have been identified and described

My dissertation focuses on the role of LARP6 phosphorylation in biosynthesis of type I collagen in fibrosis.

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27/02/2017 · Structural Biochemistry/Collagen

The double mutant, S348A/S409A, acts as a dominant negative protein in collagen biosynthesis, which retards secretion of type I collagen and causes excessive posttranslational modifications.

2018/01/05 · Type II collagen (CII) is a peptide and component of joint cartilage

N2 - The developmental changes in skin collagen biosynthesis pathway in male and female chickens were evaluated. Concentration of collagen, levels of mRNA for collagen type I subunits and for lysyl hydroxylase, and the level of three lysyl oxidase-derived cross-links: dehydro-dihydroxylysinonorleucine (DHLNL), dehydro-hydroxylysinonorleucine (HLNL), and dehydro-histidinohydroxymerodesmosine (HHMD) were determined during 4 wk posthatching. Skin collagen content increased with age and was higher in males than in females. In both sexes, the expression of the genes coding for α1and α2 of collagen type I decreased with age: α1 (I) gene expression decreased from Day 3 onwards, whereas the reduction in α2(I) gene expression started 1 wk later. At all ages examined, the expression of both genes was higher in male than in female skin. Males and females lysyl hydroxylase gene expression remained low until Day 16, after which an increase in the enzyme gene expression was observed. An increase in skin HLNL content was observed from Day 3 in both sexes reaching a peak in males at Day 9 and in females 1 wk later. The DHLNL content, which was higher in males than in females at all ages tested, dramatically decreased in both male and female skin from 3 d of age, reaching its lowest level at Day 16, and remained at that low level thereafter. The skin content of HHMD in males and females followed an oscillatory behavior with higher peaks in the male skin. The results suggest that the higher tensile strength of male skin than female skin may be due to the elevated skin collagen content that resulted from increased expression in collagen type I genes on the one hand, and from the higher amounts of various collagen cross-links on the other.

Biosynthesis of type IV collagen by cultured rat Schwann cells

Characterization of Role of LARP6 Phosphorylation in Regulating Type I Collagen Biosynthesis in Liver Fibrosis.

Of the compounds tested, apigenin glycosides 7-O-glucuronide, 7-O-methylglucuronide and pectolinarin at 30 µM were found to significantly induce collagen type I synthesis in OI fibroblasts without an effect on the overall protein synthesis.

Stimulation of collagen biosynthesis was not due to an increase in cell proliferation, because no differences in DNA content between the compound-treated and untreated cells were observed.

Stimulation of type II collagen biosynthesis and ..

Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen.

AB - The developmental changes in skin collagen biosynthesis pathway in male and female chickens were evaluated. Concentration of collagen, levels of mRNA for collagen type I subunits and for lysyl hydroxylase, and the level of three lysyl oxidase-derived cross-links: dehydro-dihydroxylysinonorleucine (DHLNL), dehydro-hydroxylysinonorleucine (HLNL), and dehydro-histidinohydroxymerodesmosine (HHMD) were determined during 4 wk posthatching. Skin collagen content increased with age and was higher in males than in females. In both sexes, the expression of the genes coding for α1and α2 of collagen type I decreased with age: α1 (I) gene expression decreased from Day 3 onwards, whereas the reduction in α2(I) gene expression started 1 wk later. At all ages examined, the expression of both genes was higher in male than in female skin. Males and females lysyl hydroxylase gene expression remained low until Day 16, after which an increase in the enzyme gene expression was observed. An increase in skin HLNL content was observed from Day 3 in both sexes reaching a peak in males at Day 9 and in females 1 wk later. The DHLNL content, which was higher in males than in females at all ages tested, dramatically decreased in both male and female skin from 3 d of age, reaching its lowest level at Day 16, and remained at that low level thereafter. The skin content of HHMD in males and females followed an oscillatory behavior with higher peaks in the male skin. The results suggest that the higher tensile strength of male skin than female skin may be due to the elevated skin collagen content that resulted from increased expression in collagen type I genes on the one hand, and from the higher amounts of various collagen cross-links on the other.

The difference in collagen type I deposition compared to mRNA levels and procollagen 1 levels may be connected to a decrease in procollagen processing.

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  • collagen type V, and procollagen 1.

    If collagen supplement would help should I be taking types 1 and 3 or type 2 collagen supplement? A.

  • "Disorders of collagen biosynthesis and structure"

    I have a collagen deficiency (Type I) and have had success with a Type I & III collagen supplement (bovine).

  • Over 90% of the collagen in the human body, however, is type I

    It is the only supplement I have found that uses collagen types I and III instead of the more common type 2.

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Type-II Collagen - Scientific Review on Usage, Dosage, …

Stimulation of collagen biosynthesis by flavonoid glycosides in skin fibroblasts of osteogenesis imperfecta type I and the potential mechanism of their action.

Collagen Supplement health benefits and medical …

Kinetics of transformation of type II to type I cells. Rats exposed to NO2 to induce lung damage were injected with [3H]thymidine at time 0 and killed from 1 h to 14 days later.

Collagen supplementation as a complementary therapy …

Improper conversion of methionine can lead to atherosclerosis, fatty liver and is associated with insulin resistance.

Mutations in this gene are associated with MTHFR enzyme deficiency and an increased risk of autism, cleft palate, depression, leukemia, cognitive impairment, Alzheimer’s disease, schizophrenia, neural tube defects, cardiovascular disease, essential hypertension, venous thrombosis, diabetic retinopathy, osteoporosis and cancers of the stomache and colon. Low levels of certain B vitamins and/or folate often determines the risk of these associated disorders. (3)

Other diseases and disorders linked to Chromosome 1 include breast cancer, Collagenopathies, type ll and Xl, Ehlers-Danlos syndrome, Factor V Leiden thrombophilia, Galactosemia , Gaucher disease, Glaucoma, Hemochromatosis , homocystinuria, Parkinson disease, porphyria and Stickler syndrome. My family and I have had testing done to rule out some of these disorders.

MTHFR Polymorphism

Skin Actives Scientific :: Product Style :: Firming Collagen Serum

We have obtained evidence that rat Schwann cells synthesize and secrete type IV procollagen. Metabolic labeling of primary cultures of Schwann cells plus neurons and analysis by SDS PAGE revealed the presence of a closely spaced pair of polypeptides in the medium of these cultures that (a) were susceptible to digestion by purified bacterial collagenase, (b) co-migrated with type IV procollagen secreted by rat parietal endoderm cells, and (c) were specifically immunoprecipitated by antibodies against mouse type IV collagen. Limited pepsin digestion of metabolically labeled medium or cell layers produced a pepsin- resistant fragment characteristic of pro-alpha 1(IV) chains. Removal of neuronal cell bodies from the cultures immediately before labeling did not reduce the amount of type IV procollagen detected in the medium. This indicated that Schwann cells, not neurons, were responsible for synthesis of type IV procollagen. We believe type IV procollagen is a major constituent of the Schwann-cell extracellular matrix based upon (a) its presence in a detergent-insoluble matrix preparation, (b) its presence in the cell layer of the cultures in a state in which it can be removed by brief treatment with bacterial collagenase or trypsin, and (c) positive immunofluorescence of Schwann cell-neuron cultures with anti-type-IV collagen antibodies. Secretion of type IV procollagen was substantially reduced when Schwann cells were maintained in the absence of neurons. This observation may account for the previously reported finding that Schwann cells assemble a basal lamina only when co-cultured with neurons (Bunge, M. B., A. K. Williams, and P. M. Wood, 1982, Dev. Biol., 92:449).

Glutaric aciduria type 1 - Wikipedia

Organization of half a type II epithelial cell from human lung (cf. Fig. ). Nucleus is enwrapped by a perinuclear cisterna () made of 2 membranes, which is traversed by nuclear pores (), shown () at greater magnification; nuclear content is divided into dense heterochromatin () areas and karyoplasm, which contains euchromatin. Cell surface is made of the plasma membrane () with a subjacent ectoplasmic layer of filaments () and a fuzzy coat or glycocalyx () on the outside (). Cells in epithelia are joined by junctional complexes () with terminal bars at the boundary between apical and lateral face; basal face is attached to the basement membrane (). Cytoplasm houses a variety of organelles, , Collagen fibrils; , endoplasmic reticulum; , Golgi complex; L, lysosomes; , lamellar body; , mitochondrion; , microtubule; , microvilli. : 1 μm, 0.1 μm ().

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