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Cardiovascular diseases and hypertension are common in the aging population. Nutritional life-style factors can help to reduce and maintain a healthy level of blood pressure. Two milk-derived tripeptides, Ile-Pro-Pro and Val-Pro-Pro, have been shown to decrease elevated blood pressure in humans and in experimental models. They also improve endothelial dysfunction and thus promote vascula...
Now that we have an understanding of the REST architectural elements in isolation, we can use architectural views  to describe how the elements work together to form an architecture. Three types of view--process, connector, and data--are useful for illuminating the design principles of REST.
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REST's client-server separation of concerns simplifies component implementation, reduces the complexity of connector semantics, improves the effectiveness of performance tuning, and increases the scalability of pure server components. Layered system constraints allow intermediaries--proxies, gateways, and firewalls--to be introduced at various points in the communication without changing the interfaces between components, thus allowing them to assist in communication translation or improve performance via large-scale, shared caching. REST enables intermediate processing by constraining messages to be self-descriptive: interaction is stateless between requests, standard methods and media types are used to indicate semantics and exchange information, and responses explicitly indicate cacheability.
A user agent uses a client connector to initiate a request and becomes the ultimate recipient of the response. The most common example is a Web browser, which provides access to information services and renders service responses according to the application needs.
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The final form of connector type is a tunnel, which simply relays communication across a connection boundary, such as a firewall or lower-level network gateway. The only reason it is modeled as part of REST and not abstracted away as part of the network infrastructure is that some REST components may dynamically switch from active component behavior to that of a tunnel. The primary example is an HTTP proxy that switches to a tunnel in response to a CONNECT method request , thus allowing its client to directly communicate with a remote server using a different protocol, such as TLS, that doesn't allow proxies. The tunnel disappears when both ends terminate their communication.
A resolver translates partial or complete resource identifiers into the network address information needed to establish an inter-component connection. For example, most URI include a DNS hostname as the mechanism for identifying the naming authority for the resource. In order to initiate a request, a Web browser will extract the hostname from the URI and make use of a DNS resolver to obtain the Internet Protocol address for that authority. Another example is that some identification schemes (e.g., URN ) require an intermediary to translate a permanent identifier to a more transient address in order to access the identified resource. Use of one or more intermediate resolvers can improve the longevity of resource references through indirection, though doing so adds to the request latency.
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For example, a Web browser that can incrementally render a large HTML document while it is being received provides significantly better user-perceived performance than one that waits until the entire document is completely received prior to rendering, even though the network performance is the same. Note that the rendering ability of a representation can also be impacted by the choice of content. If the dimensions of dynamically-sized tables and embedded objects must be determined before they can be rendered, their occurrence within the viewing area of a hypermedia page will increase its latency.
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Depending on the message control data, a given representation may indicate the current state of the requested resource, the desired state for the requested resource, or the value of some other resource, such as a representation of the input data within a client's query form, or a representation of some error condition for a response. For example, remote authoring of a resource requires that the author send a representation to the server, thus establishing a value for that resource that can be retrieved by later requests. If the value set of a resource at a given time consists of multiple representations, content negotiation may be used to select the best representation for inclusion in a given message.
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Control data defines the purpose of a message between components, such as the action being requested or the meaning of a response. It is also used to parameterize requests and override the default behavior of some connecting elements. For example, cache behavior can be modified by control data included in the request or response message.
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A representation consists of data, metadata describing the data, and, on occasion, metadata to describe the metadata (usually for the purpose of verifying message integrity). Metadata is in the form of name-value pairs, where the name corresponds to a standard that defines the value's structure and semantics. Response messages may include both representation metadata and resource metadata: information about the resource that is not specific to the supplied representation.
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